Gutless vectors encoding transgenes enhance the effect of oncolytic viruses.

2004 MAR 9 - (NewsRx.com & NewsRx.net) -- Gutless vectors encoding transgenes enhance the effect of oncolytic viruses.

According to recent research published in the journal Cancer Gene Therapy, "oncolytic adenoviral vectors selectively replicate in and lyse human tumor cells, providing a promising means for targeted tumor destruction. However, oncolytic vectors have limited capacity for incorporation of additional genetic material that could encode therapeutic transgenes and/or transcriptional regulatory control elements to augment the efficacy and/or safety of the vector. Therefore, we hypothesized that coadministration of an oncolytic vector with a …